Thứ Sáu, 31 tháng 10, 2025

How to make a perfect cuppa: put milk in first

How to make a perfect cuppa: put milk in first

 


Half the population of Britain will take this as a declaration of war. After months of research the Royal Society of Chemistry has announced the answer to a question that for generations has shattered households, sundered friendships, splintered relationships: the milk should go in first. It is all to do with denaturing milk proteins, according to Dr Andrew Stapley, a chemical engineer from Loughborough University.

There are other contentious points at issue: microwaves come into the perfect cup of tea, and the recommendation that the tea itself should be loose Assam will certainly be taken as blatant provocation by the Darjeeling and Lapsang Souchong factions.

Above all, the society could be seen as spitting on the grave of George Orwell, having commissioned the research to celebrate today's centenary of his birth - and concluded that he was quite wrong in his own recipe, published as A Nice Cup of Tea in the Evening Standard in 1946.

The chemists and the author of Animal Farm and Nineteen Eighty Four are in agreement on Indian tea, and a china or earthenware teapot. There is a minor divergence over warming the pot: Orwell recommended placing the pot on a hob, Dr Stapley defends a microwave as a 21st century equivalent. But on the issue of milk the gap is unbridgeable.

Orwell wrote: "By putting the tea in first and stirring as one pours, one can exactly regulate the amount of milk, wheras one is likely to put in too much milk if one does it the other way round."

Dr Stapley is adamant. "If milk is poured into hot tea, individual drops separate from the bulk of the milk, and come into contact with the high temperatures of the tea for enough time for significant denaturation - degradation - to occur. This is much less likely to happen if hot water is added to the milk."

Veteran tea drinker Tony Benn test-drove the perfect cup of tea yesterday, at the London headquarters of the society. He calculates that he has got through 27,375 gallons in 60 years, and is a tea first, milk second man. The milk went in first. The tea was poured in. He sniffed. He sipped. He pondered. "It's very tasty, I must say," he said. He sipped again. "Oh, it's delicious."

The chemists purred - and then last night the physicists waded in and said all that matters is the water temperature, not the milk. "Trust chemists to make things complicated," Institute of Physics chief executive Dr Julia King said. "When it boils down to it, the physics is more important than the chemical side of things."

· Chemists' recipe

The Royal Society of Chemistry's definitive recipe for the perfect cup of tea

Ingredients Loose leaf Assam tea, soft water, fresh chilled milk, white sugar.

Implements Kettle, ceramic teapot, large ceramic mug, fine mesh tea strainer, tea spoon, microwave oven.

Method Draw fresh soft water and place in the kettle and boil. While waiting for the water to boil place a tea ot containing a quarter of a cup of water in a microwave oven on full power for one minute.

Place one rounded teaspoon of tea per cup into pot.

Take the pot to the kettle as it is boiling, pour on to the leaves and stir.

Leave to brew for three minutes.

The ideal receptacle is a ceramic mug.

Pour milk into the cup first followed by the tea, aiming to achieve a colour that is rich and attractive.

Add sugar to taste.

Drink at 60-65C, to avoid vulgar slurping which results from trying to drink tea at too high a temperature.

To gain optimum ambience for enjoyment of tea aim to achieve a seated drinking position in a favoured home spot where quietness and calm will elevate the moment.

Source: https://www.theguardian.com/uk/2003/jun/25/science.highereducation 

Thứ Ba, 5 tháng 8, 2025

Compounds of the week

Compounds of the week

 

Isocarbacyclin

Isocarbacyclin1 is a synthetic analogue of prostacyclin2, a natural lipid that functions as a vasodilator and inhibitor of platelet aggregation. In 1983, Masakatsu Shibasaki, Yasuhiro Torisawa, and Shiro Ikegami* at Teikyo University (Sagamiko, Japan) reported the first synthesis of isocarbacyclin and showed that it was a more potent inhibitor than prostacyclin.

In 1990, Tadakatsu Mandai, Seiki Saito, and co-workers at Okayama University of Science (Japan) reported a highly efficient method for synthesizing isocarbacyclin. Beginning from the available (4S)-4-(tert-butyldimethylsiloxy)-2-cyclopenten-1-one, the authors assembled the two rings in the reverse order from that of earlier syntheses. A key step was a single-pot, three-step tertiary allylic vinyl ether formation, Claisen rearrangement, and ene cyclization that completed the bicyclic framework.

Almost 30 years later, Ghina’a I. Abu Deiab and Mitchell P. Croatt at the University of North Carolina at Greensboro described a synthesis of isocarbacyclin in nine steps from commercially available starting materials. Their key steps were a palladium(0)-catalyzed decarboxylation, a rhodium(I)-catalyzed cycloaddition, and a ruthenium(II)-catalyzed cross-metathesis reaction. Isocarbacyclin analogues with alternative side chains were made in seven to ten steps.

In addition to its greater efficacy than prostacyclin, isocarbacyclin is more stable than its natural counterpart. Because it inhibits platelet aggregation, it can be used for treating ischemic stroke to prevent nerve damage. As a vasodilator, it has also been studied for treating vascular disorders such as thromboangiitis obliterans and arteriosclerosis obliterans. Despite the progress in this research, a large-scale synthesis of Isocarbacyclin has yet to be developed.

1. SciFinder name: 2-pentalenepentanoic acid, 1,3a,4,5,6,6a-hexahydro-5-hydroxy-6-[(1E,3S)-3-hydroxy-1-octenyl]-, (3aS,5R,6R,6aS)-.
2. CAS Reg. No. 35121-78-9.

Isocarbacyclin hazard information*

Hazard class**GHS code and hazard statement
Acute toxicity, oral, category 4H302—Harmful if swallowedChemical Safety Warning
Skin corrosion/irritation, category 3H316—Causes mild skin irritation
Serious eye damage/eye irritation, category 1H318—Causes serious eye damageChemical Safety Warning
Specific target organ toxicity, single exposure, respiratory tract irritation, category 3H335—May cause respiratory irritationChemical Safety Warning

*No SDS available online. Data taken from AI search.
**Globally Harmonized System (GHS) of Classification and Labeling of Chemicals. Explanation of pictograms.

MOTW updates

Prednisone1 and methotrexate2 were the Molecules of the Week for June 22, 2009, and January 16, 2012, respectively. Prednisone is a glucocorticoid anti-inflammatory agent that must be used carefully because it is also an immune system suppressant. Methotrexate is a chemotherapy drug that blocks the body’s use of folic acid, but it has several side effects.

This past May, Marlies S. Wijsenbeek at the University Medical Center (Rotterdam, the Netherlands) and 22 collaborators there and at other Dutch institutions reported the results of a study of prednisone versus methotrexate as a first-line treatment of pulmonary sarcoidosis, a disease that causes abnormal collections of inflammatory cells in the lungs. Previous work assigned prednisone as a first-line treatment despite its many side effects and methotrexate as a second-line treatment, also with side effects but with a slower onset of action. The results of the authors’ 138-patient, 24-week study showed that both drugs performed equally well and that the decision between the two should be made based on the side-effect profile for each patient.

Benzene3 is the simplest six-carbon aromatic molecule and was the Molecule of the Week for July 3, 2023. It is a useful solvent and reagent but is carcinogenic and therefore less used than in the past.

The benzene ring is extremely stable; and many attempts have been made to open it under relatively mild conditions. Last month, Xiaotai Wang at Xi’an Jiaotong-Liverpool University (Suzhou, China), Jiaxiang Chu at the University of Chinese Academy of Sciences (Beijing) and Binzhou Institute of Technology (Shandong, China), and co-workers at these institutions reported the room-temperature ring opening of benzene via a four-electron reduction and carbonylation reaction. The four-electron reagents used were reduced scandium arene complexes with chromium, molybdenum, or tungsten hexacarbonyls. The resulting products were linear hexadienes bound to scandium–metal oxygenates derived from the complexes. The authors followed up by obtaining comparable results with toluene.

1. CAS Reg. No. 53-03-2.
2. CAS Reg. No. 59-05-2.
3. CAS Reg. No. 71-43-2.

See more: click here
Source: ACS

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HỌC HÓA CÙNG ChatGPT

HỌC HÓA CÙNG ChatGPT

 

HỌC HÓA CÙNG ChatGPT

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